抑郁症动物模型 z-bo 2020-08-11 630

　　1. WKY rat

　　WKY (Wistar Kyoto) rats are sensitive to a variety of stimuli, and have demonstrated behavioral defects in several general behavioral tests. In a long-term dark environment, their autonomous activities are significantly shortened and their response to light is slow, which is similar to that of human depression patients. approximate. The secretion of corticotropin, cortisol, and thyroid hormone releasing hormone in the body all have disturbances in the biological cycle rhythm. Compared with patients with depression, WKY rats are not only a better genetic behavior model of depression, but also a It is used to study the resistance of antidepressants, and to study the relationship between depression and sleep disorders in animal models of depression.

　　Two, FSL rat

　　FSL (flinder resistant line) rats have poor adaptability, with low levels of 5-HT receptors in the cortex and lower levels of neuropeptides in the hippocampus. However, the cholinergic nerve receptors are hyperactive and sensitive to cholinergic agonists, which are the same as the neurobiological changes of depression. This species of animals has the behavioral characteristics of depression. Long-term application of antidepressants can correct the above-mentioned behavioral abnormalities and can be used for the study of the cholinergic hypothesis of depression.

　　Three, HDS rats

　　HDS (high DPAT sensitive, high DPAT sensitive) rats are selective and targeted breeding models of depression genes that are highly sensitive to 5-HT1A receptor stimulants. The contrast animal with its characteristics is random DPAT sen- sitive (RDS). ) Rats, both of which can be used to study the 5-HT receptor hypothesis of depression.

　　Four, FH rat

　　FH (fawn hooded) rats like to take in a lot of ethanol and grow slowly. Their ethanol intake can be used as an indicator of antidepressant experiments. The high level of basic corticosterone and low level of insulin-like growth factor I (IGF-1) suggest that the HPA axis and HSM axis function of FH rats are abnormal. It is often used in the screening of antidepressants.

　　Five, SwLo rat

　　This model rat has less activity, weakened DA nerve function, and has more depressive behaviors: in the open field test, the immobility time in the FST and the activity in the breeding cage are reduced. Pharmacological research results show that SwLo (swim low-active model) rats can simulate atypical depression.

　　Six, TMD rat

　　TMD (Tryon maze dull) rats have low 5-HT receptor activity in the brain, showing symptoms such as slow response, reduced activity, and reluctance to eat, similar to the performance of patients with depression. The decrease of 5-HT receptor content in the brain of TMD rats may be directly related to these symptoms. This model can be used to study the causes of depression.

　　VII. Transgenic mouse model of glucocorticoid receptor gene mutation

　　Depression is related to the hyperexcitability of the HPA axis system, which may be related to impaired glucocorticoid signaling, and transgenic mice with mutations in the glucocorticoid receptor gene make the glucocorticoid receptor defective through transgenic technology. Simulating the depressive episodes induced by humans under stress, using transgenic mice with glucocorticoid receptor gene mutations combined with environmental stress to create a model that has broad prospects for development.