How to prepare an animal model of hepatitis B virus infection?
乙型肝炎,动物模型
z-bo
2020-08-11
471
Hepatitis B virus (HBV) is a hepatotropic DNA virus, which belongs to a complex DNA virus. Since the 1970s, researchers have identified Dane particles (HBV particles) under an electron microscope and clarified The surface component of HBV particles is HBsAg, the core-shell component is HBcAg, and the core component is HBeAg. HBV is a small enveloped virus. HBV DNA and HBV-specific polymerase are wrapped by a nucleocapsid into a core particle, which is then wrapped by a lipoprotein outer membrane containing HBsAg. Dane particles are highly infectious, and the infection has obvious species specificity. The susceptible host of human HBV is limited to humans and chimpanzees and other advanced primates. In recent years, chimpanzees, Peking ducks, and marmots have been used successively. , Tree shrews, bear monkeys, nude mice and other animals to establish HBV experimental infection models. At present, certain progress has been made in the research of HBV transgenic mice of the HBV genome, S genome, and X genome, and experimental animal models of ducklings and transgenic mice infected with HBV.
