动物模型,肾上腺素 z-bo 2020-08-11 529

　　[Operation steps] According to different strains of intravenous injection of 0.1% epinephrine water solution, 0.3ml/kg body weight of New Zealand rabbits, 5ml/kg body weight of Wistar rats, and 8-10ml/kg of Kunming mice. It can cause pulmonary edema in animals and die within 10-20 minutes.

　　[Analysis of results] Injecting a poisoned dose of epinephrine caused the animal to tachycardia, and the left ventricle was insufficiently diastolic, and the blood injected from the left atrium could not be fully received and discharged. In addition, the myocardium was extremely ischemic at this time, and the diastolic and systolic function decreased. This increases the pressure of the left ventricle at the end of diastole, and the pressure of the left atrial also increases, thereby hindering the return of pulmonary venous blood, making blood stasis in the lungs, increasing the hydrostatic pressure in the pulmonary capillaries, causing exudation and forming alveoli Fluid accumulation, thereby simulating cardiogenic pulmonary edema. After the animal was injected with epinephrine, typical pulmonary edema lesions, sluggishness, and irregular breathing appeared, and eventually died.