动物造模 z-bio 2023-02-01 555

　　Objective: To observe the effects of micro-arc oxidation and alkali treatment on the surface properties, biocompatibility and osteogenic ability of porous tantalum.

　　Methods: After micro-arc oxidation and alkali treatment of porous tantalum sheets, the number of micropores on the surface, calcium and phosphorus deposition and contact angle on the surface were observed by scanning electron microscope. Tantalum sheets were implanted to repair the skull defect model of rabbits, and the bone healing was observed at 4 and 12 weeks.

　　RESULTS: Scanning electron microscopy showed that the treated group had more micropores, calcium and phosphorus deposition and smaller contact angle (P<0.05). After implanting porous tantalum sheets, all animals grew well and wounds healed well. CT observation of porous The coupling between the tantalum sheet and the surrounding bone tissue was good; the detection of calcein labelling showed that new bone grew into the hollow tantalum material at 12 weeks; scanning electron microscopy showed that there were new blood vessels in the hollow tantalum material at 4 weeks, and small bone at 12 weeks. The beam grows into the material.

　　Conclusion: Micro-arc oxidation and alkali treatment can change the surface shape of porous tantalum material, and the porous tantalum sheet has good biocompatibility and osteogenic ability after treatment.