动物造模,高脂血症 z-bio 2022-04-27 261

　　Objective: To study the regulatory effect of reed root polysaccharide on hyperlipidemia rats.

　　METHODS: Thirty-two SD rats were randomly divided into 4 groups: control group, model group, reed root polysaccharide group and Lipitor group (8 rats in each group). After feeding for 8 weeks, the rats in the reed root polysaccharide group [200 mg/(kg·d)] and the Lipitor group [2 mg/(kg·d)] were given corresponding drugs by gavage, respectively. The rats in the control group and the model group were given the corresponding drugs. Normal saline was administered by gavage, blood was collected after continuous administration for 6 weeks, serum was separated to detect four lipid levels, and liver and aorta were collected for histopathological examination.

　　Results: Compared with the control group, the serum triglyceride levels in the model group were significantly decreased ( P ＜ 0.01), and the levels of total cholesterol, high-density lipoprotein cholesterol and low-density lipoprotein cholesterol were significantly increased ( P ＜ 0.01) ; Serum TC, HDL-C and LDL-C in the reed root polysaccharide group and Lipitor group were significantly lower than those in the model group (P ＜ 0.01). Rats in the model group showed extensive hepatic steatosis and inflammatory cells, while those in the reed root polysaccharide group and the Lipitor group showed relatively limited hepatic steatosis, and the degree of lesions was reduced.

　　Conclusion: Reed Root polysaccharide can reduce the levels of TC and LDL-C in rats with hyperlipidemia, alleviate hepatic steatosis, and have a good regulatory effect on rats with hyperlipidemia.