动物造模 z-bio 2022-03-04 469

　　Gadfly is an important blood-sucking arthropod, mainly sucking the blood of cattle, horses and other animals. Its adult worm is a traditional Chinese medicine, called horsefly worm, which has the effect of promoting blood circulation and removing blood stasis and breaking the accumulation of dysmenorrhea. Compendium" and other ancient medical books are recorded. In recent years, with the development of biotechnology, various active substances have been isolated and identified from different species of horsefly insects one after another, providing a biological basis for revealing the precious medicinal value of gadfly.

　　Under the leadership of Researcher Lai Ren, the Natural Medicine Functional Proteomics Group of the Key Laboratory of Animal Models and Human Disease Mechanism, Kunming Institute of Zoology, Chinese Academy of Sciences, has discovered a large number of anti-antibiotics in the salivary glands of gadfly by combining proteomics and pharmacology. Thrombus-related active protein or polypeptide (Mol Cell Proteomics. 2008 7(3):582-90; Mol Cell Proteomics. 2009 8(9):2071-9). On the basis of the above work, we conducted a series of antithrombotic and metabolic studies on Vasotab TY, one of the small peptides with vasodilation and inhibition of platelet aggregation. At the same time, experiments confirmed that the molecular mechanism of Vasotab TY exerting antithrombotic effect is through The intramolecular KGD (Lys-Gly-Asp) domain binds to platelet membrane glycoprotein IIb/IIIa (glycoprotein IIb/IIIa). The research results have been published in the journal Int J Biochem Cell Biol.