动物造模,阿尔兹海默病 z-bio 2022-03-04 481

　　New research suggests that co-existing Alzheimer's and cerebrovascular disease can worsen the symptoms of the disease. Two research groups have recently investigated this topic concurrently and have validated this conclusion from different aspects using mouse models.

　　Merphy and his team's research combined the effects of three conditions, type 2 diabetes, Alzheimer's disease and cerebrovascular disease, in mouse models. Wilcock and her team simultaneously studied the effects of Alzheimer's disease and hyperhomocysteinemia in mouse models. High levels of homocysteine are associated with many diseases, including cerebrovascular disease.

　　Both teams' studies came to similar conclusions, with no change in the first-order pathological features of Alzheimer's disease, but a more significant reduction in learning ability and memory in patients. In studies in mouse models, having both Alzheimer's and cerebrovascular disease increased disease severity. Findings like this could explain why 40 percent of Alzheimer's patients also have cerebrovascular disease, and may be helpful in treating the disease in the future.