动物造模,动脉粥样硬化 z-bio 2023-03-13 403

　　Objective To analyze the histomorphological characteristics of porcine coronary artery balloon injury lesions through a systematic review, and compare the histomorphological characteristics with human atherosclerotic plaques, so as to provide a basis for the rational application of porcine AS model.

　　Methods The databases of CNKI, Wanfang, VIP, PubMed and Web of Science were searched to screen the related researches on the minipig model of coronary artery injury caused by balloon injury. the similarities and differences.

　　Results A total of 38 literatures were included. Morphological analysis showed that lesions constructed by balloon injury often formed severe intimal hyperplasia in a short period of time, leading to lumen stenosis. The main components of the hyperplastic intima were smooth muscle cells and proteoglycans. The fibrous cap and lipid core are rare; this pathological feature is significantly different from the pathological features of atherosclerotic "fibrous cap covered with lipid core".

　　Conclusion There are morphological differences between intimal hyperplasia caused by balloon injury and AS, and it should be used with caution in lipid mechanism research and preclinical evaluation as an AS model.