动物造模,阿尔茨海默病 z-bio 2022-03-10 680

　　Objective: To investigate the characteristics of olfactory working memory impairment in the very early stage of Alzheimer's disease transgenic mice.

　　Methods: 5-week-old male 5XFAD transgenic mice and 9 wild-type mice each, and 9-week-old male 5XFAD transgenic mice and 8 wild-type mice were selected. The olfactory breadth test was used to test the olfactory breadth, the number of odor discrimination errors and the accuracy olfactory working memory ability.

　　Results: Compared with wild-type mice of the same age, 9-week-old transgenic mice had significantly lower olfactory breadth (P<0.05), significantly higher number of errors (P<0.05), and significantly lower odor discrimination accuracy (P<0.05). , compared with 5-week-old transgenic mice, the olfactory breadth of 9-week-old transgenic mice was significantly reduced (P<0.05). the="" olfactory="" number="" of="" errors="" and="" odor="" discrimination="" accuracy="" 5-week-old="" 5xfad="" mice="" were="" significantly="" different="" from="" those="" wild="" type.="" there="" was="" no="" significant="" difference="" p="">0.05).

　　Conclusion: The 9-week-old 5XFAD transgenic mice have significant olfactory working memory impairment, suggesting that olfactory working memory impairment may be a sensitive indicator of early cognitive impairment in AD mouse models.