动物造模 z-bio 2023-03-03 670

　　OBJECTIVE: To detect the reproductive function indicators and fetal developmental indicators of the embryo-fetal developmental toxicity test in Bama miniature pigs, and to provide reference data for the developmental toxicity study of Bama miniature pigs.

　　Methods: The fetuses of 12 female Bama minipigs were necropsied on the 30th, 40th, 50th, 60th, 70th, 80th, 90th, 100th, and 112th day of gestation, and the number of corpus luteum, implantation, live fetus, and absorbed fetus were counted. and the number of stillbirths, the fetal body length, tail length, and brain diameter were measured, and internal organs and bones were examined after X-ray photography.

　　RESULTS: At 40 days of gestation, the fetuses of Bama miniature pigs could be identified by gender, and the internal organs and skeletal system were basically developed. The normal values and standard deviations of various developmental indicators of minipig fetuses at different gestation days were obtained, and the 95% confidence intervals were obtained.

　　Conclusion: Bama miniature pigs can be used as the observation object of embryo-fetal developmental toxicity test. The basic data obtained in this study can provide background reference data for evaluating the reproductive toxicity test of exogenous compounds.