动物造模 z-bio 2022-06-30 593

　　Objective: To provide reference values of bone mineral density in different skeletal regions of female Wistar rats of different ages.

　　METHODS: Thirty SPF female Wistar rats were selected, and their heads, heads, and heads were measured by dual-energy X-ray absorptiometry at the age of 6 months, 10 months, 12 months, 24 months and 30 months, respectively. The bone mineral density of the upper limbs, thighs, trunk, ribs, pelvis, spine, and the whole body was compared, and the bone mineral density values between different age groups and between different bone areas of the same age group were compared.

　　Results: With the increase of month age, the BMD values of the head, upper limbs, thighs, trunk, ribs, pelvis, spine and whole body of female rats increased rapidly and reached the peak at 10 months of age; the head, upper limbs, thighs, trunk and The BMD values of the ribs were significantly or extremely significantly higher than the BMD values of the whole body at the same age (P<0.05 or P<0.01), while the BMD values of the pelvis and spine were not significantly different from the BMD values of the whole body at the same age (P<0.05 or P<0.01).>0.05), and the correlation analysis showed a significant positive correlation among the three (P < 0.01).

　　Conclusion: This paper provides some background data on bone biological indicators of female Wistar rats, which supplements basic reference materials for the study of bone metabolism in Wistar rats and its application in the field of biomedicine.