动物造模 z-bio 2022-05-31 606

　　Objective: To observe the general anesthesia effect of ketamine?Sumianxin II and midazolam mixture for induction of anesthesia, and ketamine and propofol to maintain anesthesia on Wuzhishan miniature pigs for up to 8 hours?

　　Methods: 18 Wuzhishan miniature pigs weighing (20.3 ± 1.9) kg were successfully induced anesthesia by combined ketamine-Sumianxin II and midazolam retroauricular intramuscular injection, and the mixture of ketamine and propofol was continuously pumped intravenously. The onset time and duration of induction drugs, as well as physiological indicators such as body temperature, blood pressure, heart rate and respiration, reflex activity and analgesia at 0?0.5?1?1.5?2?4?6?8 h after the miniature pigs entered anesthesia Muscle soothing effect?

　　Results: 18 were successfully anesthetized, and 4 died during the operation. The reasons were hypovolemic shock, anesthesia accident, left main thrombus and reperfusion arrhythmia? The effective time was (4.8 ± 1.2) min, and the maintenance time was (54.1 ± 5.8) min? Between 1 and 8 h, the eyelid reflex, corneal reflex and anal reflex of the miniature pigs were all dull or disappeared; The body temperature at 1 h after anesthesia was significantly different from that at 0 h (P < 0.05), and it remained stable after reaching the lowest point at 4 h. After the balloon was withdrawn, blood pressure and heart rate returned to a relatively stable level? Although breathing fluctuated, but the difference was not significant?

　　Conclusion: Ketamine, Sumianxin II and midazolam combined to induce anesthesia, and ketamine and propofol combined maintenance anesthesia have the advantages of simple operation, fast onset, relatively stable circulatory system and respiratory system during the whole process of anesthesia, and analgesia and sedation. Is it suitable for general anesthesia in miniature pigs?