动物造模 z-bio 2022-10-20 614

　　OBJECTIVE: To lay a foundation for the establishment of a clean-grade Meridian gerbil population, and to provide a reference for formulating the detection standard of Meridian gerbil parasites.

　　Methods: To investigate the parasitic infection of Meridian gerbils in a closed group, three kinds of drugs, pyrethroid, permethrin, praziquantel and tinidazole, were selected and divided into high, medium and low doses for the gerbils. Extermination of internal and external parasites in Meridian gerbils.

　　RESULTS: Two endoparasites, Trichomonas muridarum and Taenia brevis, were detected in Meridian gerbils, and the ectoparasites included the rat meat mites. The high, medium and low dose groups can kill the carnivorous mites on the body of the gerbil to different degrees. The rat meat mites can expel the rat meat on the surface of the gerbil by bathing the gerbil with 1% permethrin three times. Mites, the number of animals with mites is zero. The middle-dose group of praziquantel (31 mg/kg) had the effect of completely killing Taenia membranaceus in Meridian gerbils, and it was the optimal dose. The middle-dose group of tinidazole (42 mg/kg) was the best dose for purifying Trichomonas murine in Meridian gerbils.

　　CONCLUSION: The existing Meridian gerbils are infected with Trichomonas muridarum and Taenia brevis in vivo, and are parasitized by Rat mites in vitro. The three antiparasitic drugs have the effect of selectively expelling these parasites.