动物造模,代谢综合征 z-bio 2022-06-13 517

　　OBJECTIVE: To investigate the feasibility of two miniature pigs as metabolic syndrome model animals.

　　Methods: Bama miniature pigs and Tibetan miniature pigs were selected, and their body weight, body size, and metabolic syndrome-related indicators-blood lipids, blood glucose, and free radical levels were compared and analyzed among different species and genders.

　　RESULTS: Compared with Tibet minipigs, Bama minipigs had larger body weight, shorter body length, larger neck circumference, larger abdominal circumference and higher obesity index, and the differences were more significant in female Bama minipigs. The levels of TC, HDL-C, LDL-C and TC in female minipigs were higher than those in male minipigs. The level of GLU in Bama minipigs was higher than that in Tibetan minipigs, and was significantly different from that of female Tibetan minipigs, while the levels of FRA and HbAlc in Tibetan minipigs were higher than those in Bama minipigs, and the level of Insulin was higher in female Bama minipigs and male Tibetan minipigs. The minipigs were higher than male Bama minipigs and female Tibetan minipigs, respectively. The levels of MDA in female Bama minipigs were significantly higher than those in male Bama minipigs and Tibetan minipigs, and the levels of SOD and GSH-Px in Bama minipigs were higher than those in Tibet minipigs.

　　Conclusion: Through the analysis of normal physiological indicators such as body weight, body size, blood lipids, blood sugar and free radical levels, Bama miniature pigs tend to be obese; two types of miniature pigs have higher blood lipids in females than males; Bama miniature pigs have higher fasting blood sugar than Tibetan miniature pigs. Pigs, but the blood sugar control ability of Bama miniature pigs is better than that of Tibetan miniature pigs; the antioxidant capacity of Bama miniature pigs is better than that of Tibetan miniature pigs. In conclusion, miniature pigs of different species and sexes were selected according to specific needs in the research related to metabolic syndrome and verified with specific modeling practices.