动物造模 z-bio 2022-03-18 514

　　Objective This study was the first to evaluate the lipid-lowering effect of adding citrus polymethoxyflavone powder to biscuits in a hyperlipidemia mouse model through the measurement of lipid metabolism experimental indicators, aiming to provide a new functional food for development. in accordance with.

　　Methods Sixty male KM mice were randomly divided into 6 groups and fed for 6 weeks to establish a high-fat mouse model, and then fed with corresponding biscuits. After 6 weeks of continuous feeding, the weight, Lee's index, organ changes, Changes in liver tissue biochemical indexes and serum lipid content.

　　Results After 6 weeks, the body weight, Lee's index, organ changes, biochemical indexes of liver tissue and blood lipid content in serum all showed that polymethoxyflavonoid biscuit could inhibit the increase of body weight in hyperlipidemia mice and reduce Lee's in hyperlipidemic mice. index, improve the abnormal lipid metabolism of common biochemical indicators in the serum of hyperlipidemia model mice.

　　Conclusion Polymethoxyflavonoid biscuit can significantly improve the abnormal lipid metabolism of common biochemical indexes in serum of hyperlipidemic model mice. In terms of the effect of lipid-lowering biscuits on blood lipids in mice: lipid-lowering biscuits have a significant effect on triglycerides (TG), but have no significant effect on high-density lipoprotein (HDL-C), and also have an effect on low-density lipoprotein (LDL-C). more obvious. It is revealed that it may play a role in the treatment or health care of dyslipidemia and related diseases such as fatty liver caused by dyslipidemia