动物造模 z-bio 2022-06-06 435

　　Objective: To investigate the effects of inflammatory factors, lipid metabolism and glucose metabolism on body weight in the acute phase of AIDS.

　　Methods: SIVmac239-infected Beiping-top monkeys were detected in acute phase inflammatory factors (TNF-α, IL-6), lipid metabolism (cholesterol, triacylglycerol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol) and glucose metabolism parameters (insulin). Insulin resistance index), compared the differences between the weight gain group and weight loss group of SIV-infected flat-topped monkeys, and used Pearson correlation analysis to explore the correlation between insulin resistance and plasma viral load.

　　RESULTS: During the acute phase of SIVmac239 infection in northern flat-topped monkeys, there were no significant differences in inflammatory factors and blood lipids between the weight gain group and the weight loss group. Insulin resistance performance; Pearson analysis showed that the changes of insulin resistance index at 5 and 11 weeks after infection were positively correlated with plasma viral load.

　　CONCLUSION: In the acute phase of SIVmac239 infection, abnormal glucose metabolism may be the main reason for the body weight change of northern flat-topped monkeys.