动物造模 z-bio 2022-10-10 378

　　Objective: To study the effect of simple portal hypertension on serum endotoxin and intestinal mucosa in rats?

　　Methods: 16 rats were selected and divided into blank control group (4 rats) and model group (3 d group? 7 d group? 10 d group, 4 rats in each group). Blood, jejunum, ileum and colon of rats were collected from 3 d to 7 d to 10 d, and serum endotoxin content was detected by ELISA to observe the changes of endotoxin. observation analysis?

　　Results: The rats in the model group were all successfully established the partial portal vein ligation model? There was no significant difference between the results of serum endotoxin at three different time points and the normal control group? After 3 days of modeling, the intestinal segment did not develop a great deal of damage. injury; 7 days after modeling, the intestinal villi of each intestinal segment were partially destroyed and swollen compared with 3 days, and the connection between epithelial cells and lamina propria appeared loose; The intestinal mucosa and the lamina propria were obviously damaged?

　　Conclusion: In the case of normal liver function, portal hypertension can cause intestinal mucosal damage in a short time, but the endotoxin produced in the intestine will not exceed the processing capacity of the liver and the increase of serum endotoxin will occur?