动物造模,局灶性脑缺血 z-bio 2022-03-29 434

　　OBJECTIVE: To investigate the effects of intermedin and adrenomedullin on cerebral microcirculation in rats with focal cerebral ischemia.

　　Methods: The middle cerebral artery occlusion method was used to establish a rat model of cerebral ischemia, and 40 SPF male SD rats were randomly divided into 3 groups: cerebral ischemia model + normal saline [CI + NS (normal saline, NS)] group , CI model + ADM treatment (CI + ADM) group and CI model + IMD treatment (CI + IMD) group, using laser Doppler measuring instrument to monitor the changes of brain surface microcirculation perfusion.

　　Results: There were significant differences in the microcirculation perfusion volume on the brain surface of the CI+NS group, CI+ADM group and CI+IMD group (P<0.05). The perfusion volume of microcirculation was higher than that of CI+NS group and CI+ADM group.

　　Conclusion: IMD can improve cerebral microcirculation in rats with focal cerebral ischemia, and the curative effect is better than that of ADM.