动物造模 z-bio 2023-03-03 479

　　OBJECTIVE: To study whether pine pollen has attenuating and synergistic effects on paclitaxel combined with platinum-based chemotherapy.

　　Methods: Forty-eight nude mice with transplanted tumors prepared from human lung cancer H460 cell line were selected and divided into model group, three doses of pine pollen 600, 300 and 150 mg/kg + TP regimen chemotherapy group, and TP regimen alone according to the principle of tumor volume balance. Chemotherapy group and three single-dose groups of pine pollen 600, 300, and 150 mg/kg alone, with 6 rats in each group. After each group was given corresponding drugs, the body weight, food intake, tumor inhibition rate, hematology and liver and kidney function of nude mice were used as evaluation indicators to comprehensively evaluate whether pine pollen had synergistic and detoxification effects on TP chemotherapy.

　　Results: The model animals were given TP chemotherapy and intragastric administration of pine pollen (150, 300, 600 mg/kg), which significantly improved the tumor inhibition rate of TP chemotherapy alone, and inhibited the weight loss and food intake caused by chemotherapy drugs. , Inhibition of chemotherapy-induced leukopenia and liver and kidney function damage.

　　Conclusion: The simultaneous administration of pine pollen with TP regimen chemotherapy has obvious synergistic and detoxification effects.