动物造模,流感病毒,动物实验 z-bio 2022-03-30 349

　　Influenza viruses are prone to worldwide pandemics due to their rapid mutation, rapid spread, general susceptibility to the population, and difficulty in control. The human influenza pandemics that have occurred since the 20th century include the 1918 H1N1 Spanish influenza, the 1957 H2N2 Asian influenza, the 1968 H3N2 Hong Kong influenza, and the new type A H1N1 influenza that swept the world in 2009. Significant economic losses and social panic. In addition, since the outbreak of H5N1 highly pathogenic avian influenza in humans in Hong Kong, my country in 1997, the cross-species transmission of avian influenza virus (AIV) has also attracted great attention, and the number and areas of human infection with avian influenza have continued to increase. . In 2013, an outbreak of H7N9 occurred in my country; in May of the same year, Taiwan reported the first case of human infection with H6N1 avian influenza virus; at the end of 2013, there was another case of H10N8 infection in China; in 2014, the first human cases of H5N6 infection occurred in Sichuan and Hunan in my country.

　　In order to deal with a possible influenza pandemic, study the pathogenic mechanism of influenza virus, and develop new influenza vaccines, many laboratories around the world are carrying out influenza research, and animal infection experiments with influenza virus are an indispensable part of these studies. Since influenza virus animal infection experiments have certain risks, which will pose a threat to the health of researchers and the public, countries have strict regulations on the level of biosafety laboratories required for animal infection of different types and subtypes of influenza virus. In this paper, the relevant domestic and foreign regulations, standards and literature are reviewed, and the biosafety classification and biosafety management of influenza virus animal infection experiments are discussed for reference by peers who carry out influenza virus infection animal experiments.