动物造模 z-bio 2022-11-15 646

　　Objective: To investigate the anti-fatigue effect of maca extract on sports.

　　Methods: 50 male Wistar rats were randomly divided into: ① control group: normal feeding, no swimming, gavage with the same volume of distilled water; ② simple swimming group: swimming, gavage with the same volume of distilled water; ③ swimming + drug administration group: swimming, And respectively gavage maca extract 4.0, 8.0 and 16.0 g/(kg·bw). 10 animals per group. The rats were given 4.0, 8.0 and 16.0 g/(kg·bw) maca extract for free swimming in circulating water for 15 consecutive days. On the 16th day, samples were taken to measure liver lipid peroxidation (LPO) and superoxide disproportionation. enzyme (SOD), glutathione peroxidase (GSH-Px) and liver glycogen levels.

　　Results: Compared with the pure swimming group, after 15 days of administration of maca extract 4.0, 8.0 and 16.0 g/(kg·bw), the sinking times of the rats decreased by 27.44%, 42.86% and 64.11%, respectively (P<0.01). ), the swimming time before sinking and the total swimming time were prolonged by 18.99%, 64.46%, 90.69% and 37.12%, 56.23% and 94.72% respectively (P<0.01), and the LPO level was decreased by 31.31%, 42.00% and 56.95% respectively. (P<0.01), SOD, GSH-Px and liver glycogen levels increased by 25.92%, 31.82%, 62.09%, 12.33%, 23.01%, 46.36% and 17.83%, 44.69%, 62.99%, respectively (P<0.01 ).

　　Conclusion: Maca extract can reduce the level of liver LPO, increase the level of liver glycogen, improve the activities of SOD and GSH-Px, enhance exercise endurance and anti-fatigue.