动物实验 z-bo 2020-08-17 574

　　Researchers at the Harvard Stem Cell Institute (HSCI) have published two consecutive papers in the journal Science. These papers previously discovered the proteins that make the dysfunctional hearts of old mice look like the hearts of young healthy mice. confirm. Similarly, the brain and skeletal muscle function of old mice was improved. Professors Amy Wagers and Leeubin of Harvard University's stem cell and regenerative biology are the senior authors of these two papers. They report that injection of a protein called GDF11 (GDF11 found in mice and humans) can improve the exercise capacity of 70-year-old mice and improve the olfactory function of the brains of older mice. .. -They can recognize smells like mice. They said that if no accidents happen, they hope to promote GDF11 to human clinical trials within 3 to 5 years.

　　These two studies investigated the effects of GDF11 in two ways. In the first study, the researchers used a so-called coupled biological system to connect two mice through surgery and circulate the blood of young mice to older mice. The second study was to inject GDF11 into old mice. In previous studies, Weighers and Richard Lee of Brigham and Richardichard, one of the authors of these two papers, confirmed that GDF11 is sufficient to reverse certain characteristics of cardiac aging. Doug Melton, deputy director of the Harvard Stem Cell Institute, said: "This is the most exciting research discovery. It is the most primitive experiment in stem cell science. It brings us hope for a healthier future. More powerful , Think faster. These two exciting research papers with rare findings point to a practical answer: GDF11 protein levels are high when you are young, at least it seems insignificant; in some animals, GDF11 is aging Muscle. And has an amazing ability to restore brain function. Wegers has studied the function of each organ system so far, a postdoctoral fellow at Stanford University 14 years ago. She and her colleagues observed that the blood of young mice is older The circulation of mice in the body seems to affect the injury after injury. Recovery produces some regenerative effects: In 2013, she and Richard Lee (Richard Lee) in another paper, when exposed to the blood of young mice At time, the hearts of old mice expanded and weakened, regaining their young size and functioning. Then, we reported an improvement, and then worked with a company in Colorado to confirm that GDF11 in the blood was clearly responsible for this regeneration effect. The reason for this makes GDF11 irreversible in the elderly. We hope that people have the potential to treat fatal diastolic heart failure:

　　Wagers: "According to previous research, GDF11 appears to be heart-specific. A new study shows that GDF11 is activated in multiple organs and cell types." Recovered and improved performance in running and grip tests. "It is well known that the brains of old mice are in very poor condition, which reduces the frequency of neurogenesis and reduces cognitive ability."

　　In a new study, researchers found that neural stem cells increased. We observe an increase in the development of blood vessels in the brain. .. 3D brain reconstruction and magnetic resonance imaging (MRI) results of mice showed that there are many new blood vessels and blood flow, usually associated with young, healthy brain tissue. Rubin said: "Young mice have a strong sense of smell. When I tested young mice, I avoided the mint smell, while older mice did not.

　　Ubin said: "GDF11 improves blood vessels and blood flow, and is believed to be related to increased neurogenesis. GDF11 should at least in principle have a broader effect on other areas of the brain. A method is needed to use proteins that can reverse specific aging degradation. The molecule GDF11 or GDF11 itself may be able to reverse age-related damage. The drug developed is of great significance to Alzheimer’s disease. "We believe we have the funds to implement it. "There is no doubt that some combination of this research and other studies will translate into clinical trials and treatments. Of course, this is just a bet."