干细胞 z-bo 2020-08-17 495

　　A few days ago, researchers from Sun Yat-sen University’s Eye Center and a team from the University of California San Diego discovered for the first time that WNT7A and PAX6, the key elements that regulate the differentiation of corneal stem cells, play an important role in corneal lineage differentiation. It is proved that it induces skin stem cells, differentiates into limbal stem cells and restores corneal function normally. This represents a new strategy for the treatment of corneal diseases.

　　The representative of the

　　project said that borderline stem cell transplantation has been limited by the lack of donor resources and rejection of allogeneic transplantation. The importance of the findings published in the journal Nature is that they can quickly and cheaply distinguish skin epithelial stem cells or other types of cells, and expand enough limbal stem cells to repair and regenerate the corneal surface. possible. , The treatment of limbal stem cell deficiency provides potential resources. This provides a broad application prospect for the treatment of major diseases caused by limbal stem cell dysfunction and the repair of epithelial damage after myopia.

　　The above results are the products of the National Institute of Ophthalmology, Sun Yat-sen University. On the platform of the national leading laboratory, the operating mechanism of "open, mobile, collaboration, and competition" is actively used. We conduct joint research and joint research. Key personnel responsible for the results include Professor Zhang Kang, director of the Human Genome Medicine Institute at the University of California, San Diego, director of the Ophthalmology Center at Sun Yat-sen University, and Liu Yizhi, director of the Eye Hospital.