动物造模,糖尿病 z-bio 2023-04-20 424

　　Objective: To investigate the dynamic changes and regularities of blood physiological and biochemical indexes during the cultivation of diabetic inbred strains of gerbils.

　　Methods: Referring to the previous research methods, biochemical analyzers and blood cell analyzers were used to detect 17 blood biochemical and 22 blood routine indexes of the inbred F9~F14 generation of diabetic gerbils, and draw their dynamic curves.

　　Results: From the test results and dynamic curve changes, the uric acid (URIC), lactate dehydrogenase (LD), creatine kinase (CK), amylase (AMY), blood glucose (GLU), mononuclear Cell percentage (MON%), mean hemoglobin content (MCH), mean hemoglobin concentration (MCHC), mean platelet volume (MPV) showed an upward trend with the increase of generations; total cholesterol (CHOL), direct eosinophil count (EOS), The percentage of eosinophils (EOS%), red blood cells (RBC), hematocrit (HCT), hemoglobin (HGB) showed a downward trend; albumin (ALB), total protein (TP), triglyceride (TG), high The overall trend of other indicators such as density lipoprotein (HDL), urea nitrogen (BUN), total bilirubin (TBIL), creatinine (CRE), alkaline phosphatase (ALP) and aspartate aminotransferase (AST) was relatively stable.

　　Conclusion: The blood physiology and biochemistry in the breeding of diabetic inbred animals will change with the increase of inbreeding generation, especially the related indexes of glucose metabolism and lipid metabolism are higher than those of other animals, which indicates the disease characteristics of diabetic animals, and also indicates that the directional close relatives Reproduction and cultivation have certain effects on their blood physiological and biochemical indicators.