金属蛋白酶,猪蓝耳病 z-bo 2020-08-18 542

　　Porcine Reproductive and Respiratory Syndrome, also known as "pig blue ear disease", is characterized by skin cyanosis. In 1992, the World Health Organization classified the disease as a category B infection, but the disease has now spread widely in all countries in the world. Since 2006, my country has developed a PRRS disease characterized by persistent high fever, high morbidity and high mortality. This virus continues to infect pigs, causing immune suppression in the body and animals. May cause bacterial and viral infections. It caused severe losses to China's pig industry. Although researchers around the world have extensively studied this disease, its infection requires further study of the pathogenic mechanism of virus-host interaction.

　　According to Wang Yu'e, members of the metalloproteinase family are able to cleave cell surface molecules and participate in and control the growth and development of the human body. Although existing studies have shown that metalloproteinase 17 is involved in the onset and development of diseases such as cancer and inflammation, there is no report on whether this enzyme can regulate PRRS infection. Researchers Wang Yue and Dr. Guo Longjun discovered that activated metalloproteinase 17 can prevent PRRS virus from infecting target cells.

　　"Further studies have shown that activated metalloproteinase 17 can down-regulate the viral receptor CD163 on the surface of target cells and inhibit viral infection. Therefore, metalloproteinase 17 may be an important innate immune molecule for the body to fight infection.