动物造模,骨质疏松 z-bio 2022-06-23 305

　　Objective To observe the therapeutic effect of bakuchiol on castration-induced osteoporosis in male mice.

　　Methods ICR male mice were randomly divided into 5 groups, namely control group, castration model group, positive drug group, bakuchiol 10 mg/kg and 20 mg/kg body weight groups. mouse testis. After 6 weeks of successful modeling, mice were administered for 8 weeks, and the samples were collected to detect serum biochemical indexes.

　　Results The OC values of osteocalcin in the control group, model group, B10 and B20 mg/kg groups were (177.69±45.13), (220.35±25.08), (167.48±74.11) and (108.76±38.17), respectively; , positive drug group, B10 and B20mg/kg group Tb.N were (3.53±0.49), (1.71±016), (2.51±0.35), (2.14±0.23) and (2.45±0.42).

　　Conclusion Bakuchiol has a therapeutic effect on osteoporosis induced by castration in dimensional mice.