暴饮暴食 z-bo 2020-08-18 525

　　Binge eating usually refers to people who swallow large amounts of food without restriction in a short period of time. People usually define bulimia as a bad lifestyle. About 10% of American adults have the bad habit of bulimia.

　　Data shows that women with irregular menstrual cycles are more likely to overeating. This shows that overeating is closely related to estrogen. High estrogen inhibits overeating, and low estrogen leads to frequent overeating. In order to study the relationship between bulimia and estrogen, the researchers established a mouse model and found for the first time that estrogen can strongly inhibit bulimia in mice. This is very consistent with human data. Researchers speculate that women with irregular menstrual cycles are more likely to overeating, which may be related to impaired estrogen function. Further studies have shown that the estrogen receptor mediates the inhibitory effect of estrogen on bulimia and determines the location of the receptor.

　　In a mouse model, researchers found that estrogen alpha receptors expressed on brain-mediated estrogen serotonin neurons can inhibit the effects of bulimia. The researchers said that the importance of this study not only reveals the mechanism by which estrogen regulates roaring behavior, but more importantly, it opens up a way to use estrogen to treat rooster behavior. This is expected. Estrogen therapy has caused controversy due to its side effects, and can easily cause breast cancer. Researchers say that only by fully understanding the role of estrogen, understanding its advantages and disadvantages, and avoiding its disadvantages, can side effects be avoided and the development of estrogen therapy can be promoted. The researchers said that Indiana University researchers have developed a conjugated compound called GLP-1-estrogen that can be released in areas where both GLP-1 and estrogen receptors are present. The conjugated compound does not deliver estrogen to the breast tissue, so it does not increase the body risk when controlling breast cancer. The researchers used this conjugated compound to treat mice and found that the estrogen-like activity in the serotonin neuron region of the mouse brain was significantly increased. This indicates that the conjugated compound can deliver estrogen to this area. , Estrogen and GLP-1 can prevent bulimia behavior. Earlier studies have shown that GLP-1 levels in bulimia patients are reduced, but no one has found that GLP-1 can interfere with bulimia behavior in humans or animals. Recent studies have shown that both GLP-1 and estrogen can suppress appetite, while the complex compound of GLP-1 estrogen can bypass breast tissue and is affected by estrogen-α, which is controlled by serotonin neurons in the brain expression.

　　is displayed on the body part. Next, the researchers hope to determine how estrogen regulates serotonin neurons and whether increasing serotonin levels can suppress bulimia.