动物造模 z-bio 2022-06-24 364

　　Objective To investigate the effects of different exercise interventions on emotional behavior of aggressive rats.

　　Methods Fifty 12-week-old SPF male SD rats were randomly divided into 5 groups after one week of adaptive feeding: quiet (A) group, aggressive model (G) group, aggressive platform (GT) group, and aggressive treadmill (GP) group. Group and invasion (R) group, single-cage feeding + foreign rat invasion was used to establish a rat attack model, and the changes in the emotional behavior of the attacked model rats were observed, and two exercise modes, platform jumping and treadmill exercise, were used to intervene for 8 weeks. The rats in the treadmill group were trained for 3 days per week, and the treadmill group was trained for 5 days per week. The rats in each group were subjected to open field experiments in the middle and late stages of training to observe the changes in the emotional behavior of the rats after exercise intervention.

　　Results During the experiment, the exploratory behavior, activity level and autonomous activity level of the rats in the attack model group (G) were significantly reduced, and the emotional anxiety and tension were higher. After 4 weeks of platform exercise and treadmill exercise intervention, the attack platform ( The GT) group and the attack treadmill (GP) group had significant differences in the number of standings, the number of crosses and the number of modifications. The average speed, central activity time and total distance of the two groups of rats increased significantly. In model (G) group, the behavioral changes such as excitability, exploratory behavior and self-attention were improved to varying degrees, and the influence of platform exercise on rat behavior was more obvious. After 8 weeks of platform exercise and treadmill exercise intervention , the excitability of the rats in the attack platform (GT) group and the attack treadmill (GP) group was significantly improved, but the excitability, exploratory behavior and spontaneous activity of the rats after the treadmill exercise intervention were significantly reduced, which was similar to the attack model ( G) group had no significant difference.

　　Conclusion Appropriate platform exercise and treadmill exercise can significantly improve the anxiety, tension and action behavior of aggressive rats.