动物实验,心脏病,中风 z-bo 2020-08-19 455

　　During a heart attack or stroke, blood clots can cause heart and brain ischemia and hypoxia. If the blood clot falls off and the blood flows back into the heart or brain, it can cause further damage. But so far, it is not clear how the restoration of blood flow causes this damage.

　　In a paper published in the journal Nature on November 5, scientists from the Department of Mitochondrial Biology, MRC Cancer Department and University of Cambridge of the Medical Research Council (MRC) stated that their first discovery was The chemical substance of succinate. Accumulation can cause this damage. When sugar and fat are broken down and the energy stored in the body is released, succinic acid will naturally appear in the body. according to

　　Research, limited blood flow can cause abnormally high levels of succinic acid in organs. When the blood flow returns, the excess accumulated succinic acid will interact with oxygen as it enters the hypoxic tissue. This releases destructive molecules, which damage and destroy muscle cells in the organ.

　　In the months or years after a heart attack, this injury may eventually lead to heart failure. This is a debilitating disease that prevents people from performing daily activities such as bathing and climbing stairs. use

　　Researchers in

　　mice have used a technique called metabolomics to detect a series of different chemicals in vital organs before and after heart attacks and strokes, thereby increasing the content of succinate. I have already determined. Importantly, administration of a simple compound called malonate when blood flow is restored can reduce organ damage in mice and rats. Malonic acid prevents the accumulation of succinic acid and the release of destructive molecules. Malonates are very cheap and easily available, and are naturally found in fruits such as strawberries, apples, and grapes, but their content is not enough to be beneficial. These findings also affect organ transplant operations, such as the kidney, liver, and heart, which are damaged when connected to the blood of transplant patients.

　　The co-author of the paper, Dr. Michael Murphy from the Department of Mitochondrial Biology, MRC, noted: "This study describes the mechanism of organ damage in the recovery of blood flow in the first few minutes after a heart attack or stroke, and the importance of the mechanism. Preventing this Kind of damage."

　　"We use simple chemicals found in everyday fruits (such as apples and grapes) and are not considered to have a healing effect. Dr. Thomas Krieger from the Department of Clinical Pharmacology, University of Cambridge said:"

　　Another co-author of the paper, he said: "Serious sequelae of these diseases. Currently, there are no conventional drugs to prevent this damage, but our research shows that simple, inexpensive compounds can significantly improve heart attacks. And the prognosis of stroke patients. Now, we hope to carry out this research further and get effective treatment within 5-10 years."