动物实验 z-bo 2020-08-19 460

　　It is not uncommon to use colds to treat diseases. For example, the ancient Greek doctor Claudius Gallen used colds to treat fever, severe battlefield injuries, and improved surgical efficiency. In the 1950s, hypothermia was used as a tool to improve the side effects of brain surgery. Nowadays, more and more evidences also show that colds are an effective way to treat neonatal cerebral hypoxia.

　　However, it was not until 1987 that scientists solved this mystery. It has been found that colds can reduce neurodeath after brain injury. The latest article by ature also pointed out that when the body temperature is low, the protein will be released, which will affect the brain's ability to remodel nerve cross-linking and the overexpression of the protein can be used to treat degenerative diseases. In cold dormancy, organisms will produce large amounts of various proteins. These are the so-called "cold shock proteins". One of them is RBM3. Although this protein is involved in preventing brain cell death, scientists are not sure how RBM3 affects synaptic degeneration and regeneration. Understanding how these proteins activate synaptic regeneration may help scientists find ways to prevent synapse loss without actual cooling.

　　In this study, the researchers lowered the body temperature of healthy mice to 16-18°C. This is similar to the hibernation temperature of small mammals and is maintained for 45 minutes. As a result, they found that these non-hibernating mice also began to enter the process of cold salvage regeneration and warm-up. Later, researchers found that mice with neurodegenerative diseases (Alzheimer's disease and viral diseases) decreased their body temperature as the disease progressed, lost the ability to regenerate synapses, and lost RBM3,

　　But artificially increasing the level of RBM3 protein can protect mice from Alzheimer's disease and virus infection, prevent the loss of synapses and brain cells, as well as the symptoms of memory loss and life extension. I have found that. Therefore, the researchers said, RBM3, which may contain other cold shock proteins, affects the ability of neurons to regenerate synapses in the process of neurodegenerative diseases, and neurodegenerative diseases are the key to the treatment of this disease. I believe it is possible. Therefore, this method can be used as a drug target to protect brain cells without actual cooling. Giovanna Mallucci, who led the study, said: “Sometimes it turns out that the cold slows down and can even prevent brain cell damage, but in clinical practice, lowering body temperature is impractical. There are pneumonia and blood clots. Risk. To prevent brain cell loss, we hope to develop a drug that mimics this protective effect by enabling this method.