糖尿病,转基因鼠 z-bo 2020-08-19 550

　　Scientists have been studying diabetes in mice for a long time. The DNA of these mice has been altered by the human growth hormone gene. A new study conducted by the Catholic University of Leuven in Belgium found that the gene affects insulin production in mice. confirmed. The important parameters of this discovery have led to the need to reinterpret many diabetes studies based on this genetically modified mouse. Transgenic mice have been used in medical research for more than 30 years. In order to speed up the replication process of DNA fragments, the pioneers of this method inserted the human growth hormone gene into the transgenic DNA. The researchers hypothesized that human growth hormone DNA is tightly contained in the genetically modified DNA of mice. They did not expect that mice would produce human growth hormone by themselves, which is a fact discovered by the researchers. Professor Frans Schuit and Professor John Creemers of Rubin Catholic University use genetically modified mice extensively in the laboratory. Unexpectedly, they observed that these mice showed suspicious pregnancy symptoms even if they were not pregnant. Further investigation revealed that these pregnancy-like conditions are caused by human growth hormone.

　　Hugh explained: "The effect of human growth hormone on mice is the same as that of hormones produced in the placenta of pregnant mice. Just like during pregnancy, placental cells will cause changes in insulin production. Increasing the number of cells will produce more insulin. It is precisely the insulin we hope to use these "infected" mice for research in our diabetes research, Professor Kramer continues. "In many such studies, researchers try to find out whether there is a specific effect in insulin production. The role of genes. The results of transgenic mice are skewed. This is caused by human growth hormone. The role of this gene in research has been overestimated or underestimated, and these results need to be reinterpreted. "

　　"At the same time, there are many genetically modified mice that do not contain human growth hormone. These mice explain the previous results." Professor Hitt concluded that taking a step back and correcting wrong assumptions is part of the scientific method. "Even if this means slowing down the progress of scientific research, we must strictly review the methods we use. For diabetes research, this unexpected discovery is an important step forward. Now, the problem of artificial growth of hormones has been solved. This allows scientists to plan future research more clearly."