动物实验,神经毒性 z-bo 2020-08-19 532

　　Since MSG was first discovered in 1908, research on MSG has mainly focused on its potential neurotoxicity. The US Food and Drug Administration has identified monosodium glutamate (MSG) as a safe food that can be used in the food industry. Recent studies have found that MSG may be related to the development of obesity, and related discussions are intense. In order to further confirm the influence of MSG on human metabolism, Yin Yulong, a scholar at the Institute of Subtropical Agricultural Ecology of the Chinese Academy of Sciences, has systematically used pigs as an animal model in the past three years.

　　MSG affects the intestinal microbial composition and the overall redox state of the intestinal tract of growing pigs, which in turn affects the composition of fatty acids in the intestine and the concentration of toxins in the intestinal tract. It has then been found that it affects intestinal permeability and promotes fatty acids. The absorption of iron and other nutrients interferes with the body’s energy balance, affects the central nervous system through endocannabinoid signaling pathways, triggers the gene network of food regulation and energy balance regulation, and affects liver fat production, inactivation and degradation of it, Improve the body's ability to perceive fatty acids, change the supply of fatty acids in muscle and adipose tissue, and ultimately promote the deposition of fat in muscle and adipose tissue, and promote obesity.

　　In addition to MSG, considering modern diet, fat is also the main factor inducing obesity. The research team also studied the interaction between MSG and fat in the diet. Studies have shown that MSG and fat have a variety of mechanisms to promote obesity, and they have an antagonistic effect on promoting obesity. The results of this study not only clarified the mechanism of dietary fat and monosodium glutamate on the energy balance and feeding regulation of growing pigs, but also provided guidance for reducing human obesity. Do it. The research results are published in journals such as Amino Acids, PLoSONE, Obesity Facts, Applied Physiology, Nutrition, Metabolism, and BiologicalTraceElement Research. The research results have promoted the widespread application of sodium glutamate and other functional amino acids in the pig industry at home and abroad, bringing more than 1.5 billion yuan in social and economic benefits each year.