动物造模 z-bio 2022-07-15 379

　　Objective: To study the effect of resveratrol on the formation of hypercoagulable state in rats and its relationship with the expression of NF-κB.

　　Methods: SD rats were divided into blank group, model group, high-dose resveratrol group (60 mg/kg), low-dose resveratrol group (30 mg/kg) and aspirin group (10 mg/kg). After 7 days of intragastric administration, a hypercoagulable rat model was established by epinephrine combined with ice bath and thrombin method, and blood samples were collected to measure prothrombin time (PT) and activated partial thromboplastin time (activated partial thromboplastin). time, APTT) and whole blood viscosity; vascular endothelial cells were collected, and the expression of NF-κB was detected by Western blotting.

　　Results: Compared with the model group, PT and APTT in the blank group, high-dose resveratrol group and aspirin group were significantly prolonged (P<0.05), and blood viscosity was significantly decreased (P<0.05); vascular endothelial cell NF in high-dose resveratrol group The expression of -κB was significantly lower than that in the model group (P<0.05).

　　Conclusion: High-dose resveratrol (60 mg/kg) can inhibit the formation of blood hypercoagulable state in rats, and this effect may be related to the decrease in the expression of NF-κB.