动物造模 z-bio 2022-07-19 311

　　Objective: To preliminarily explore whether music affects the learning and memory ability of adult mice.

　　Methods: 80 C57 mice were randomly divided into 10 groups, half male and half male in each group. Blank control group: no music stimulation was given, 3 groups of high-frequency music, 3 groups of medium-frequency music, and 3 groups of low-frequency music, respectively, were stimulated with three pieces of high-frequency, medium-frequency, and low-frequency music, 5 hours a day, for 6 consecutive days. On the 7th day, the water maze test was performed, during which the musical stimulation was kept unchanged. The test indicators were the latency period, the number of platform passes and the platform quadrant residence time.

　　RESULTS: Compared with the blank group, the escape latency of the mice in the music group was significantly shortened (P<0.05). although="" the="" number="" of="" times="" passing="" through="" platform="" and="" time="" spent="" in="" quadrant="" difference="" was="" not="" significant="" p="">0.05). There was no significant difference in the detection indexes between the music groups (P>0.05).

　　Conclusion: The selected 9 pieces of music can improve the learning and memory ability of adult mice, and there is no significant difference in the effects of different frequencies of music. It is speculated that the influence of musical stimulation on mice is closely related to the standard of music classification, the length of stimulation period, and the selection of stimulation time points.