动物造模,2型糖尿病 z-bio 2023-02-28 510

　　Objective: To observe the changes of insulin sensitivity in the liver and peripheral tissues of type 2 diabetic rats at different times after RYGB and to preliminarily explore the possible mechanism.

　　Methods: The RYGB group (n=21) and the RYGB sham operation group (n=7) were treated with extended hyperinsulinemic-euglycemic clamp in awake state to evaluate the insulin sensitivity of liver and peripheral tissues at 2, 4, and 8 weeks after RYGB. . The levels of TG in liver and gastrocnemius were detected.

　　Result: RYGB operation can reduce body weight, reduce body fat, and improve lipid metabolism. Two weeks after operation, the hepatic insulin sensitivity index was significantly increased, and the hepatic TG content was significantly decreased (P<0.05). At 4 weeks after operation, the M value was significantly increased, and the muscle TG content was significantly decreased (P<0.05).

　　Conclusion: The improvement of liver insulin sensitivity after RYGB is earlier than that of peripheral tissues, and the continuous improvement of insulin resistance in liver and peripheral tissues is helpful for long-term remission of type 2 diabetes. The reduction of liver and skeletal muscle fat deposition by RYGB may be one of the important mechanisms for the up-regulation of postoperative insulin sensitivity.