动物造模 z-bio 2022-07-19 227

　　Objective: To study whether pine pollen has synergistic and attenuating effects on cyclophosphamide chemotherapy.

　　Methods: The ascites S180 mice were used as the experimental system to evaluate the synergistic and attenuating effects of pine pollen on cyclophosphamide chemotherapy by detecting tumor inhibition rate, hematology and liver function indicators; the immunocompromised mouse model was used as the experimental system , by detecting the phagocytic function of giant cells, the level of hemolysin and the index of thymus and spleen, the immunomodulatory effect of pine pollen was evaluated.

　　Results: Pine pollen (150, 300, 600 mg/kg) combined with cyclophosphamide significantly improved the tumor inhibition rate, significantly inhibited the leukopenia and liver function damage caused by cyclophosphamide, and improved the mononuclear cells of immunocompromised mice. Phagocytosis, hemolysin levels, and immune organ coefficients of phagocytes.

　　Conclusion: Pine pollen can significantly synergize and reduce toxicity of cyclophosphamide chemotherapy by regulating immunity.