动物造模 z-bio 2022-07-20 364

　　Objective: To investigate the changes of hematological indexes in the long-term toxicity test of Niaotongkake Naiqi tablets in rats.

　　Methods: 120 SD rats, half male and half male, were randomly divided into the control group and the low-dose, medium-dose and high-dose groups of Nietongkake Naiqi Tablets. The control group was given 0.5% sodium carboxymethyl cellulose suspension by gavage, and the low-dose, medium-dose, and high-dose groups were given Naitongkakenaiqi tablets 0.32 g, 1.6 g, and 3.2 g (crude drug)/kg·g by gavage, respectively. d, 6 days a week, for 180 consecutive days, the general condition, blood cell changes, blood biochemical changes, electrolytes and blood coagulation indexes of rats were observed on 90 d, 180 d and 30 d after drug withdrawal respectively.

　　RESULTS: No death or obvious toxicity was found in the rats during the experiment. Compared with the control group, the rat red blood cell count (RBC), hemoglobin (HGB), mean corpuscular hemoglobin content (MCH), mean corpuscular hemoglobin concentration (MCHC), platelet count (PLT), white blood cell count (WBC), lymphatic Cell percentage (LYMP%); alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), glucose (GLU), urea nitrogen (BUN), white Protein (ALB), total bilirubin (TBIL), creatinine (Crea), total cholesterol (TCHO), triglyceride (TG), creatine phosphokinase (CK); potassium ion concentration (K+), sodium ion concentration ( Na+), chloride ion concentration (Cl-), and prothrombin time (PT) were statistically different (P < 0.05-P < 0.01), but there was no time and dose regularity, and no pathological significance.

　　CONCLUSION: There is no obvious abnormality in the blood indexes of rats after gavage of the raw powder of Nietongkakenaiqi tablets at doses of 0.32 g, 1.6 g and 3.2 g (crude drug)/kg·d for 180 days. safe.