动物造模,神经干细胞,皮肤细胞 z-bo 2020-08-19 539

　　Porcine skin cells help develop new therapies to treat human destructive neurological diseases. Recently, scientists at the University of Georgia have successfully transformed pig-induced pluripotent stem cells into artificial neural stem cells through research. Related research "Stem Cells and Development" is an international journal; this research is based on the same process as the development of human neural stem cells, and may help to understand the causes of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease . Researcher Steven Stice (Steven Stice) for the first time actually implemented an animal blueprint project that can be used to simulate the process of human diseases, which helps to more clearly analyze and understand the causes of human neurological diseases. In earlier studies, researchers stopped using early cell populations for research and instead used porcine embryonic stem cells for research. These stem cells are a very rare source and can differentiate into unexpected cell types, including nerve cells, liver cells, and even muscles. Cells

　　In this study, the researchers characterized the characteristics of pig skin stem cells and induced differentiation into neural stem cells. We also confirmed that special markers of porcine skin stem cells may induce neural differentiation. The original researchers believed that the adult brain cannot be treated with stem cell therapy, nor can it produce new neurons for regeneration. The current problem is that after the induced pluripotent stem cells are put into the brain, they can transform into any type of cell and form a tumor. Cell type. Researchers first extracted cells from pig skin, reprogrammed them to form induced pluripotent stem cells, and then used protein marking technology to identify these skin stem cells. It is said that the cells have been induced into neurons. It can help produce millions of nerve cells. Advanced technology has transferred research from the test bench to clinical research. It may no longer be a dream. However, so far, researchers have had to conduct a lot of tests to observe and summarize. The problem of the past has been solved, because the neurons can function in the future, and now researchers have simulated the same developmental pathway in pig cells.

　　Finally, in short, researchers, our ultimate goal is to use new technologies to induce more neural stem cells, and to develop new targeted therapies to treat human neurodegenerative diseases. Let me do.