动物造模,急性肺损伤 z-bio 2023-04-21 436

　　Objective: To investigate the effect of arginine antidiuretic hormone (AVP) on pulmonary edema fluid clearance in patients with acute lung injury.

　　Methods: Forty-eight healthy adult male SD rats were randomly divided into control group, model group (ALI group), and AVP group. The lung histopathology, lung water content, alveolar epithelial permeability and alveolar fluid clearance were observed in each group. (AFC) changes, and the expression of alveolar epithelial sodium channel (ENaC) and sodium/potassium ATPase (Na+, K+-ATPase) was determined.

　　Results: After AVP treatment, the alveolar epithelial permeability (0.27±0.15 vs 0.59±0.19) and pulmonary water content (5.01±1.59 vs 8.67±1.79) in the model group were reduced, and the AFC increased (23.56±4.51 vs 8.28±3.57). , α-ENaC (1.296±0.322 vs 0.349±0.141) and α1-Na+, K+-ATPase expression increased (1.421±0.389 vs 0.338±0.186), all of which were significantly different (P<0.05).

　　Conclusion: AVP can promote AFC, and its action pathway may be achieved by up-regulating α-ENaC and α1-Na+, K+-ATPase channel proteins.