动物造模 z-bio 2022-07-21 454

　　Objective: To investigate the effects of different animal experimental anesthetics on the cardiovascular system of rats.

　　Methods: BioPac MP150 was used to dynamically record the electrocardiogram and blood pressure of rats after anesthesia with four kinds of anesthetics, and the blood glucose of rats at different time points after anesthesia as well as the experimental end points of liver and kidney function, myocardial enzymes and electrolytes were collected.

　　Results: Chloral hydrate can cause severe ventricular arrhythmia, isoflurane has inhibitory effect on heart rate, pentobarbital sodium can increase the P wave of electrocardiogram in rats, and urethane can cause the elevation of J point of electrocardiogram in rats. Urethane and pentobarbital sodium can both cause SBP to increase, chloral hydrate can increase CK, isoflurane can reduce CK and CKMB, pentobarbital sodium and isoflurane can reduce ALT and AST. Chloral hydrate, sodium pentobarbital and isoflurane can reduce creatinine, and the four anesthetics can reduce blood sodium and potassium.

　　Conclusion: Chloral hydrate has obvious effects on the cardiovascular system and is not suitable for animal experimental research on cardiovascular disease. Sodium pentobarbital, urethane and isoflurane can be appropriately selected as animal experimental research on cardiovascular disease.