动物实验,干细胞迁移 z-bo 2020-08-19 642

　　Recently, a group of pig genetic engineering and genetic resources innovation teams from the Beijing Institute of Animal and Veterinary Medicine of the Chinese Academy of Agricultural Sciences and Peking University School of Medicine revealed a mechanism that regulates the migration of piglet mesenchymal stem cells. Related results were published in "Stem Cell Research and Treatment". on. Miniature pigs are ideal large-scale animal models for tissue repair and cell therapy research, as well as a donor of important biological materials for tissue repair. Porcine and human MSCs are highly similar in immunophenotype and cellular functional characteristics.

　　According to Mu Yulian, head of the Institute of Zoology, mesenchymal stem cells are a type of adult stem cells that can proliferate and differentiate in the body. Ability is an important factor affecting its repair and therapeutic efficacy. In this study, quantitative proteomics techniques were used to compare and analyze the differentially expressed proteins of two mesenchymal stem cells from the bone marrow and umbilical cord of Wuzhishan mini-pig inbred line. It is in a signaling pathway related to cell migration.

　　The results of phenotypic analysis showed that the migration ability of bone marrow mesenchymal stem cells was significantly higher than that of umbilical cord mesenchymal stem cells, which is directly related to the key regulatory proteins of cell migration. Using miniature pigs as a model to study MSC can effectively solve the problem of individual differences caused by the source of the donor. At the same time, this research will help clarify the tissue-specific functions of adult stem cells and provide reference data for animal models for tissue repair and targeted therapy based on mesenchymal stem cells.