动物造模 z-bio 2022-07-26 351

　　OBJECTIVE: To investigate the effect of curcumin on the survival rate of rats in the desert hot and dry environment.

　　Methods: Forty male SD rats aged 6-8 weeks of SPF grade were selected and randomly divided into control group, low-dose curcumin pretreatment group, curcumin medium-dose pretreatment group, curcumin high-dose pretreatment group, and solvent group. The control group was fed normally; the low-dose group, the middle-dose group, the high-dose group, and the solvent group were given equal volume of intragastric administration for 7 consecutive days. It was placed in an artificial experimental cabin in a special environment in the northwest region, and the climate model of the desert hot and dry environment was set (temperature 41°C, humidity 10%, and ultraviolet radiation 40W/m2). The vital signs of the rats in each group were observed and the change of core body temperature was monitored every half hour, and the time of death was recorded.

　　RESULTS: The five groups of rats were placed in the desert dry heat environment for 0-30 min, and the core body temperature of the three curcumin dose groups was not significantly different from that of the control group and the solvent group (P>0.05). Starting from 60 min, at 60 min, 90 min, 120 min, 150 min, 180 min, 210 min, and 240 min at 7 time points, the core body temperature of the low-dose group, middle-dose group, and high-dose group was lower than that of the control group and the solvent group. , the difference was significant (P<0.05). 0="" 240="" from="" to="" p="">0.05). The average survival time of rats in the control group, curcumin low, medium and high dose treatment group and solvent group was (222.95±28.23)min, (231.35±40.96)min, (255.00±30.39)min, (263.80±56.71) respectively )min, (223.00±27.23)min. The survival time of rats in the middle and high dose curcumin pretreatment groups was significantly longer than that in the low concentration pretreatment group, the control group and the solvent group (P<0.05), and the high dose group had a significant effect (P<0.01).

　　Conclusion: Curcumin pretreatment can improve the survival time of rats in desert dry heat environment, suggesting that curcumin may play an important role in improving the heat tolerance of desert dry heat environment rats, and curcumin may play an important role in the prevention and treatment of heatstroke in desert dry heat environment It has potential clinical application value.