动物实验,埃博拉病毒 z-bo 2020-08-20 515

　　Researchers have discovered a series of laboratory mice that work under strict biosafety conditions and can respond to Ebola virus like humans, from deadly hemorrhagic fever to full tolerance. Their results indicate that genetic components play an important role in determining disease outcome, and its mouse disease model may be useful for screening candidate therapies and vaccines.

　　Angela Rasmussen and colleagues tested the effects of Ebola virus on co-hybrid mice, which represent a hybrid of five classic laboratory mouse strains and three wild-type strains. Some mice are sensitive to this virus, while others are resistant to it.

　　So far, there is no Ebola mouse model that can reproduce the characteristic symptoms of Ebola. This includes delayed blood clotting, internal bleeding and brown blood. Asmussen and her team also studied the genomes of these coordinated hybrid mice. An allele called Tek (known to activate clotting factors) may affect a person's sensitivity to the virus.