动物实验,转基因 z-bo 2020-08-20 642

　　Studies have pointed out that parabens can be used to turn genetic modification on and off. Now, researchers have discovered a relatively simple way to switch transgene expression. This is a major advancement in the development of targeted therapy. This method requires a shower.

　　Martin Fussenegger, a biotechnology scientist at the University of Basel, pointed out that the research team has developed a "design" cell that can be implanted into the human body and turned on or off by a remote trigger. Wesenegal said: "This is not a swallowing drug, because it is first excreted from the liver. This method is better than injections, and injections are invasive." The only non-invasive method of protein therapy. Paraben is a plant-based antibacterial agent, usually used as a cosmetic preservative, but because it can quickly move from the skin to the blood, it can be used as an ideal trigger. Another advantage is that it has been approved by the FDA and can be used in ready-made daily chemicals such as shower gel, hand cream and toner. Benzoic acid disrupts the metabolic pathways of the pathogen Pseudomonassyringae and may cause bacterial spots on tomato plants. Using this sensitive interaction of parabens, Husenegar and his colleagues designed a set of mammalian gene switches that allow paraben-sensitive transgenes to be expressed in a variety of human cell lines.

　　Husenegger: "The advantage is that by adding more or less parabens to the shower gel, we can reach a critical amount in the blood that is related to the specific expression of therapeutic proteins." The research team was treated with parabens. Acid ester activation We have found that an optimized transgenic system can cause the expression of the reporter gene SEAP in mammalian HEK-293 cells.

　　Husenegger: "In the future, I will not take prescription drugs several times a day. Taking several baths a day can adjust protein therapy."