姜黄素,动物实验 z-bo 2020-08-20 472

　　Objective: To study the effect of curcumin on the survival rate of rats in arid and hot desert environment.

　　Method: Forty SPF male SD rats aged 6-8 weeks were randomly divided into control group, low-dose curcumin pretreatment group, medium-dose curcumin pretreatment group, high-dose curcumin pretreatment group, and the excipients were divided into . group. The control group was fed with normal feeding, low-dose, medium-dose, high-dose and vehicle groups were given equivalent intragastric doses for 7 days. Located in the artificial experiment cabin in the special environment in the northwest, a desert dry high-temperature environment climate model (temperature 41°C, humidity 10%, ultraviolet light 40W/m2) is set. Observe the vital signs of each group of rats, monitor changes in core body temperature every 30 minutes, and record the time of death.

　　Result: Five groups of rats were placed in a dry and high-temperature environment in the desert for 0-30 minutes, and the core body temperature of curcumin in the three dose groups was not significantly different from that of the control group and the solvent group (P\→0.05). Starting from 60 minutes, 60 minutes, 90 minutes, 120 minutes, 150 minutes, 180 minutes, 210 minutes and 240 minutes, the core body temperature of the low, medium and high dose groups was lower than that of the group, the difference was statistically significant (P \ u003c0.05). In the control group, the average survival time of curcumin low, medium and high dose treatments and the 5 vehicle groups were (222.95±28.23) minutes, (231.35±40.96) minutes, (255.00±30.39) minutes and (263.80±56.71), respectively ). ) Minutes, (223.00±27.23) minutes. The survival time of rats in the high-dose curcumin pretreatment group was significantly longer than that of the low-concentration pretreatment group. The survival time of the control group and the vehicle group (P<u003c0.05), the high-dose group had a significant effect.

　　Conclusion: Curcumin pretreatment can prolong the survival time of rats in the desert dry and hot environment. Curcumin can improve the heat tolerance of rats in the desert dry and hot environment. Curcumin may play an important role. Heatstroke can be dry and hot in the desert. Occurs in the environment, and has potential clinical application value in prevention and treatment.