动物造模,急性心肌梗死 z-bio 2022-09-01 225

　　Objective: To observe the changes of left ventricular cardiac function in cynomolgus monkeys with acute myocardial infarction by echocardiography, and to provide reference for the application of cynomolgus monkey AMI model.

　　Methods: The cynomolgus monkey AMI model was examined by echocardiography before modeling, 3 days after modeling, and 1 month after modeling, to observe left ventricular morphology, hemodynamics, mitral valve orifice blood flow velocity and Changes in the velocity of valve annulus tissue movement. Results Compared with before modeling, the posterior wall thickness of left ventricular end-diastole in cynomolgus monkeys increased significantly (P<0.05) 3 days after modeling (P<0.05), and the left ventricular end-systolic diameter was modeled for 1 month. At the same time, the left ventricular ejection fraction, stroke volume and left ventricular short-axis fraction were significantly decreased at 3 days and 1 month after modeling in cynomolgus monkeys (P < 0.05, P < 0.01); cardiac output was significantly decreased at 1 month after modeling (P < 0.05), while heart rate (HR) was significantly increased at 3 days after modeling (P < 0.05).

　　Conclusion: Echocardiography can be applied to the evaluation of left ventricular cardiac function in the cynomolgus monkey AMI model; especially the LVEF, SV, LVFS indexes can reflect the degree of AMI; the echocardiographic evaluation results of the cynomolgus monkey AMI model are consistent with the ultrasound of human AMI disease. Cardiac findings were similar.