动物实验,阿尔茨海默病 z-bo 2020-08-20 583

　　Will it exacerbate Alzheimer's disease? Animal studies similar to the treatment of human Alzheimer's disease indicate that the treated antibodies may actually be harmful. It has been found that antibodies that have undergone clinical trials in humans can destroy the sticky plaques that form in the brain. In a mouse model of Alzheimer's disease, antibodies seem to activate brain cells in the same way and eventually stop functioning.

　　"We believe this may be the failure mechanism of these antibodies in human trials," said Mark Butcher of the Technical University of Munich, Germany. Bush and his colleagues gave Alzheimer's disease model mice and normal mice the same antibody drugs. After treatment, it was found that the activity of the affected brain cells was 5 times that of normal mice. Plaques rupture When Alzheimer's plaques form, fragments called beta-amyloid will accumulate. Busche et al. previously found that β-amyloid protein can cause neuronal hyperactivity. They believe that when antibodies destroy these plaques, they make this effect somewhat worse than when they keep the plaques intact.

　　In the process of trying to treat Alzheimer's disease, after many failures, drug developers began to try to detect and treat the disease as early as possible. Therefore, Busche and his team even studied the effects of drugs on early Alzheimer's disease in these mice. At this moment, there are no plaques in their brains, their neurons are more active, and the disease worsens. symptom.

　　mice may be misleading

　　" It was found to work in very young mice before plaque was deposited. The cause of ADHD is still unknown.

　　However, Maria Carrillo, chief scientific officer of the Zheimer Society of these drugs, said that other researchers were cautious in stating that the mouse experiment had misleading results.

　　Busche agrees that the mouse model cannot simulate all aspects of human diseases. This is a combination of multiple methods.