动物造模,阿尔茨海默病 z-bio 2022-09-05 391

　　Alzheimer's disease is an age-related irreversible neurodegenerative disease of unknown etiology. The clinical manifestations are mainly cognitive and memory loss.

　　At present, the exploration of the pathogenesis of the disease and the efficacy of drug therapy has become one of the hot spots in modern brain research, but its complex pathogenesis and pathological changes have posed a major challenge to the selection of experimental animal models.

　　In this paper, the characteristics of commonly used experimental animal species, the selection of various animal models and the method of model construction are reviewed in detail. Commonly used animal models of AD can be divided into natural animal models, physical intervention models, chemical intervention models, genetic intervention animal models, and other types.

　　This paper summarizes and comments on the methods of constructing these models, pathological changes and applicable types of experiments, hoping to provide reference for researchers to select and establish experimental animal models.