动物造模,血管性认知障碍动物模型 z-bio 2022-09-06 346

　　Vascular cognitive impairment is one of the hot spots of medical research in recent years. The etiology of the disease is complex, and its clinical manifestations include multi-cognitive disorder, memory impairment, and dementia, which seriously affect the quality of life of patients. The successful establishment of an animal model of chronic cerebral ischemic vascular cognitive impairment is the first step in medical research to study its pathogenesis, provide treatment and overcome the disease.

　　After development, there are a variety of VCI animal modeling methods, most of which are rodents. For rats, there are four-vessel occlusion method, modified 4-VO method, 3-stage 4-VO method, and two-vessel occlusion method (2-vessel occlusion method). occlusion, 2-VO) method, modified 2-VO method, and one side common carotid artery occlusion and one side common carotid artery stenosis method, etc.; for mice, there are common carotid artery stenosis and asymmetric carotid artery surgery. According to the different surgical modeling methods used, there are certain differences in the postoperative pathological injury site, injury degree, survival rate, and animal behavioral performance of animals.