动物造模,2型糖尿病 z-bio 2022-09-09 285

　　Objective To observe the changes of blood glucose in a mouse model of type 2 diabetes mellitus, and to explore the feasibility of 2 h postprandial blood glucose as an evaluation point for blood glucose intervention.

　　Methods Healthy C57BL/6 mice were selected, and the experimental group of type 2 diabetes mellitus (T2DM) was induced by high-fat diet plus streptozotocin (STZ), and a normal control group was established. The continuous fasting blood sugar and continuous random blood sugar were measured in the two groups respectively, the blood sugar regularity of the mice was analyzed, and the scientificity of the 2-h postprandial blood glucose as a blood glucose intervention evaluation point in T2DM mice was evaluated; The stability of the post-2h blood glucose intervention evaluation point.

　　Results The continuous fasting blood glucose of T2DM mice showed that the blood glucose change range was relatively stable during the 2-3 h postprandial fasting period. After fasting for more than 4 h, the blood glucose of the T2DM mice continued to decrease significantly, while the normal group could slowly increase and maintain the blood glucose. Relatively stable; 2h postprandial blood glucose fluctuations in T2DM mice within 7 weeks showed that 2h postprandial blood glucose was stable.

　　Conclusion The 2-h postprandial blood glucose can stably reflect the blood glucose changes in the T2DM mouse model, and has a good application value in the evaluation of blood glucose intervention experiments.